Durability of responses in patients with metastatic renal cell carcinoma treated with high dose interleukin-2 (HD IL-2)

Results The overall response rate (ORR) and mOS are described in Table 1. In the retrospective cohort, the 1, 2, and 3 year survival rates were 89%, 69%, and 61% respectively for patients with stable disease (SD). Similarly, in the prospective cohort, 1 and 2 year survival rates for patients with SD were 95% and 76%, respectively. The mOS was not reached for patients with SD in both cohorts. There was a significant difference in mOS between SD and PD patients in the prospective cohorts, NR vs 13.9 months, p < 0.0001, there was no significant difference in mOS between SD and PD in the retrospective cohort. For patients in the retrospective and prospective cohorts who had prior targeted therapy (TT), the mOS was 15.3 and 22.1 months, respectively. Patients who did not receive TT before HD IL-2 therapy, the mOS was 48.9 months and NR, in the retrospective and prospective cohorts, respectively. There were 4 treatment-related deaths in 408 patients.